Sulthiame has been used for the treatment of focal epilepsy of childhood with central temporal spikes. Other studies suggest that it may be effective in children and adults with a range of drug resistant epilepsies.
Sulthiame should not be used in cases of known hypersensitivity to sulphur-containing medications, other sulphonamides and in patients with known acute porphyria, hyperthyroidism or arterial hypertension.
All medications have side effects. Not everyone will experience side effects. Below are some of the possible side effects your child may experience.
Common side effects
- Paraesthesiae of the extremities and face
- Increased respiratory rate and dyspnoea
- Dizziness, drowsiness, unsteadiness, headache, double vision
- Loss of appetite and weight loss
- Slowed thinking
- Gastric complaints
- Increased saliva
Severe and rare adverse effects
- Renal impairment
- Severe rash including Steven-Johnson syndrome and toxic epidermal necrolysis
- Metabolic acidosis and kidney stones, altered electrolytes
- Anxiety, hallucinations and mood changes
- Your doctor will check and make sure that other drugs your child is taking are compatible with sulthiame.
- Sultiame may Interact with other medications including phenytoin, phenobarbitone, primidone, carbamazepine, lamotrigine.
- Sulthiame should generally not be used in patients already receiving acetazolamide, topiramate, or the ketogenic diet, because these also predispose to metabolic acidosis and kidney stones.
Epilepsy and Pregnancy
- There are currently no controlled studies in humans but animal studies show adverse effects so classified as category D.
- Effects that sulthiame may have on the foetus should be discussed with your Doctor.
- Any issues related to childbearing please refer to: www.PENNSW.org.au.
Monitoring and Levels
- Timing of checks of blood count, renal function and liver function tests will be determined by your doctor.
What else do I need to Know?
- Drugs with a sulphur base may cause an allergic reaction. If fever, sore throat, swollen lymph nodes, or flu-like symptoms occur, contact your doctor.
- If you have any further questions, please consult your treating doctor.
The information provided in this handout is limited and does not replace the need for a medical consultation. It is very important you speak to your doctor about all aspects of your medication including side effects when medication is first prescribed. Report any concerns to your doctor promptly.